@pipeworx/opentargets

Connect: https://gateway.pipeworx.io/opentargets/mcp · Install: one-click buttons

Tools: 7

Open Targets MCP — disease/target/drug knowledge graph that integrates genetic, genomic, transcriptomic, and chemistry evidence. Keyless GraphQL public endpoint.

Tools

• target(ensembl_id) — target (gene) profile
• disease(efo_id) — disease profile
• drug(chembl_id) — drug profile
• search(query, entity?, size?) — platform search
• target_associations(ensembl_id, size?) — top diseases for a target
• disease_associations(efo_id, size?) — top targets for a disease
• target_known_drugs(ensembl_id, size?) — clinically tested drugs for a target

Data source

https://api.platform.opentargets.org/api/v4/graphql

Tools

• target — “Drug target profile for [gene]” / “is [gene] a druggable target” / “[gene] target info” / “target ID [ENSG…]” — fetch a drug-target profile (Open Targets uses Ensembl gene IDs as target identifiers
• disease — “Disease profile for [EFO_N]” / “look up disease [ID]” — fetch a disease profile from Open Targets by EFO (Experimental Factor Ontology) ID. Returns name, description, therapeutic areas, ontology cros
• drug — “Drug info for [ChEMBL ID]” / “look up [drug] target info” / “[CHEMBL…] mechanism” — fetch a drug profile from Open Targets by ChEMBL ID. Returns name, mechanisms of action, indications, target gene
• search — “Find [disease / drug / gene target]” / “Open Targets lookup for [name]” / “what’s the Open Targets ID for [X]” — text search across diseases, drug targets, and drugs in the Open Targets Platform (the
• target_associations — “What diseases is [gene] involved in” / “diseases associated with [target]” / “what does [gene] cause” — top disease associations for a drug target (Ensembl gene ID), scored by integrated Open Targets
• disease_associations — “Best drug targets for [disease]” / “what genes are linked to [condition]” / “druggable targets in [disease]” — top drug-target candidates for a disease (EFO ID), scored by integrated evidence. Use fo
• target_known_drugs — “What drugs target [gene]” / “approved drugs against [target]” / “clinical-trial drugs for [gene]” — drugs that have been clinically tested or approved against a drug target (Ensembl gene ID). Returns