g:Profiler

liveBiologyScience

g:Profiler (University of Tartu) — functional enrichment analysis for a gene list against GO, KEGG, Reactome, WikiPathways, TRANSFAC, miRTarBase, CORUM, HPA and HPO, plus gene/protein ID conversion and cross-species ortholog mapping. Keyless.

3tools
0msauth
free tier50 calls/day

Tools

gprofiler_enrich

"What pathways are enriched in [gene list]" / "run GO enrichment on these genes" / "what biological processes do [genes] share" / "functional annotation of my differentially expressed genes" — AUTHORI

No parameters required.

▶Try it
gprofiler_convert_ids

"Convert these gene symbols to Ensembl IDs" / "what is the Ensembl/Entrez/UniProt ID for [gene]" / "map my probe IDs to gene names" / "translate this gene list into [namespace]" — AUTHORITATIVE identi

No parameters required.

▶Try it
gprofiler_orthologs

"What is the mouse ortholog of [human gene]" / "find the human equivalent of [zebrafish/fly/yeast gene]" / "map this gene list to [species]" — AUTHORITATIVE cross-species ortholog mapping (g:Orth) via

No parameters required.

▶Try it

Test with curl

The gateway speaks JSON-RPC 2.0 over HTTP POST. You can test any pack directly from the terminal.

List available tools
bash
curl -X POST https://gateway.pipeworx.io/gprofiler/mcp \
  -H "Content-Type: application/json" \
  -d '{"jsonrpc":"2.0","id":1,"method":"tools/list"}'
Call a tool
bash
curl -X POST https://gateway.pipeworx.io/gprofiler/mcp \
  -H "Content-Type: application/json" \
  -d '{"jsonrpc":"2.0","id":2,"method":"tools/call","params":{"name":"gprofiler_enrich","arguments":{}}}'

Use with the SDK

Install @pipeworx/sdk to call tools from any TypeScript/Node project.

TypeScript
import { Pipeworx } from '@pipeworx/sdk';
const px = new Pipeworx();
const result = await px.call("gprofiler_enrich", {});
ask_pipeworx
// Or ask in plain English:
const answer = await px.ask("g:profiler (university of tartu) — functional enrichment analysis for a gene list against go, kegg, reactome, wikipathways, transfac, mirtarbase, corum, hpa and hpo, plus gene/protein id conversion and cross-species ortholog mapping");