Civic

liveHealth

CIViC — Clinical Interpretation of Variants in Cancer.

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Tools

civic_search_genes

Find cancer genes and fusions in CIViC by name or symbol, with how much curated clinical evidence each carries (variant count, evidence-item count, assertion count). AUTHORITATIVE starting point for "

No parameters required.

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civic_gene_variants

Curated variants of a cancer gene in CIViC — the specific alterations (missense, fusion, amplification, exon-level) that have published clinical interpretations, each with its evidence count, associat

No parameters required.

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civic_variant_evidence

Individual CIViC evidence items for a molecular profile — the graded, source-linked statements that a variant predicts response or resistance to a therapy, carries prognostic or diagnostic weight, or

No parameters required.

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civic_assertions

CIViC assertions — the curated, AMP/ASCO/CAP-tiered and ACMG-classified clinical summaries that roll up multiple evidence items into a single actionable statement, including FDA companion-test and reg

No parameters required.

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Test with curl

The gateway speaks JSON-RPC 2.0 over HTTP POST. You can test any pack directly from the terminal.

List available tools
bash
curl -X POST https://gateway.pipeworx.io/civic/mcp \
  -H "Content-Type: application/json" \
  -d '{"jsonrpc":"2.0","id":1,"method":"tools/list"}'
Call a tool
bash
curl -X POST https://gateway.pipeworx.io/civic/mcp \
  -H "Content-Type: application/json" \
  -d '{"jsonrpc":"2.0","id":2,"method":"tools/call","params":{"name":"civic_search_genes","arguments":{}}}'

Use with the SDK

Install @pipeworx/sdk to call tools from any TypeScript/Node project.

TypeScript
import { Pipeworx } from '@pipeworx/sdk';
const px = new Pipeworx();
const result = await px.call("civic_search_genes", {});
ask_pipeworx
// Or ask in plain English:
const answer = await px.ask("civic — clinical interpretation of variants in cancer");