query
Pack: myvariant · Endpoint: https://gateway.pipeworx.io/myvariant/mcp
Search aggregated human genetic-variant annotations on MyVariant.info. Accepts an rsID (“rs58991260”), an HGVS id (“chr1:g.218631822G>A”), or a fielded query (“dbnsfp.genename:CDK2”, “clinvar.rcv.clinical_significance:pathogenic”). Each hit merges dbSNP, ClinVar clinical significance, CADD/dbNSFP deleteriousness scores, and gnomAD population allele frequencies. Returns { total, hits }; hit._id is usually the HGVS id you can pass to the variant tool.
Parameters
| Name | Type | Required | Description |
|---|---|---|---|
query | string | yes | rsID, HGVS id, or fielded query. e.g. “rs58991260”, “chr1:g.218631822G>A”, “dbnsfp.genename:CDK2”. |
fields | string | no | Comma-separated return fields (default: all). e.g. “dbsnp,clinvar,cadd.phred,gnomad_genome.af”. |
size | number | no | Max hits to return, 1-1000 (default 10). |
Example call
curl -X POST https://gateway.pipeworx.io/myvariant/mcp \
-H 'Content-Type: application/json' \
-d '{"jsonrpc":"2.0","id":1,"method":"tools/call","params":{"name":"query","arguments":{}}}'Connect
Add this to your MCP client config, or use one-click install buttons:
{
"mcpServers": {
"myvariant": {
"url": "https://gateway.pipeworx.io/myvariant/mcp"
}
}
}See Getting Started for client-specific install steps.