@pipeworx/inxight-drugs

Connect: https://pipeworx.io/mcp — every tool in the catalog, including @pipeworx/inxight-drugs’s. Install: one-click buttons

No MCP client? Skip the connection: POST https://gateway.pipeworx.io/v1/tools/search_packs {"query":"..."} to find a tool below, GET /v1/tools/<name> for its schema, POST the same URL with arguments for the data — see For AI agents.

Tools: 3

Drug development status by indication from NCATS Inxight Drugs: for any drug or substance, the conditions it is approved for or in trials for, the highest phase reached per condition, its approval history, originator and targets.

Tools

• inxight_substance(name | unii) — one substance by name or FDA UNII: every indication with its highest phase (Approved / Phase III / II / I) and the trial or label URL behind it, the overall highest development event, first approval year, originator, targets with pharmacology and potency, synonyms, and ChEMBL / DrugBank / PubChem / CAS / MeSH / RxCUI ids. Answers “what is psilocybin being developed for, and how far along”.
• inxight_search(query, development_status?, limit?, offset?) — free-text substance search; returns UNIIs plus breakdowns of the hits by development status, highest phase and condition.
• inxight_indication(condition, development_status?, limit?, offset?) — substances for a disease, each with the highest phase reached FOR THAT condition. development_status: "Clinical" keeps only investigational drugs. Also returns the related condition labels Inxight uses (“Ischemic stroke”, “Acute ischemic stroke”) for drilling down.

An unknown drug or condition returns found: false with a reason and a hint; an upstream HTTP error throws.

For mechanism of action and target-disease evidence, use the chembl and opentargets packs — inxight_substance returns the ChEMBL id to hop across. For individual trials, use clinicaltrials.

Auth

Keyless.

Data sources

Inxight Drugs (https://drugs.ncats.io) is run by NIH’s National Center for Advancing Translational Sciences. It is a GSRS deployment that joins the FDA Global Substance Registration System with ClinicalTrials.gov, DrugBank, Drugs@FDA, DailyMed and orphan designations. The site is an Angular app; the JSON API it calls is public but undocumented. Endpoints used, all GET:

• https://drugs.ncats.io/api/v1/substances/search?q=psilocybin&top=10 — search. Exact-name match is q=root_names_name:"^PSILOCYBIN$"; UNII lookup is q=root_approvalID:"2RV7212BP0". Filter with repeated facet=<Facet Name>/<value>, e.g. facet=Condition/Stroke and facet=Development Status/Clinical (facets AND together).
• https://drugs.ncats.io/api/v1/substances/search/@facets?kind=ix.ginas.models.v1.Substance&field=Condition&ffilter=stroke&fetch=25 — the condition labels containing a string, with counts. Facet values are case-sensitive, so inxight_indication resolves the caller’s text here first.
• https://drugs.ncats.io/api/v1/substances(<uuid or UNII>)?view=full — names and code cross-references.
• https://drugs.ncats.io/api/v1/substances(<uuid or UNII>)/@additional — the Inxight layer: a flat list of {name, value} records. The ones used are Conditions (per-indication highestPhase + highestPhaseUri), Targets, Stitcher Highest Phase, Highest Development Event, Earliest Approved Event, Approval Year, Originator, Description.

Things worth knowing:

• An unrecognized id in substances(<id>) answers HTTP 500 (“Invalid UUID string”), not 404 — which is why UNII lookup goes through search instead.
• Conditions always carries a placeholder row labelled Unknown; it is dropped.
• Search order is the upstream’s, not relevance or phase. inxight_indication re-sorts the page it fetched by phase for the condition.
• Condition phases come from a ClinicalTrials.gov snapshot (the Stitcher Label records say e.g. “ClinicalTrials, February 2021”), so a programme that moved phase recently can read one phase behind. Check clinicaltrials for the latest trial.

Tools

• inxight_substance — Drug development status by indication from NCATS Inxight Drugs: for one drug or substance (by name or FDA UNII), every condition it is approved for or in clinical trials for with the highest phase rea
• inxight_search — Search NCATS Inxight Drugs substances by free text (drug name, synonym, code, company or condition words), optionally narrowed to a development status (US Approved Rx, US Approved OTC, US Previously M
• inxight_indication — Drugs and substances approved for or in clinical development for a condition, from NCATS Inxight Drugs: give a disease or indication (e.g. “stroke”, “major depressive disorder”, “migraine”) and get ea