target_interactions

Pack: guidetopharmacology · Connect: https://pipeworx.io/mcp (see Connect below for a single-pack URL)

No MCP client? Call it directly: GET https://gateway.pipeworx.io/v1/tools/target_interactions for the schema, then POST the same URL with its arguments for the data.

List the quantitative ligand interactions for a protein target in the Guide to PHARMACOLOGY (IUPHAR/BPS). Given a GtoPdb target id (from search_targets), returns the ligands acting on it with interaction type (Agonist/Antagonist/Inhibitor/etc.), action, and binding affinity (e.g. pKi/pIC50). Requires a GtoPdb API key — register free at guidetopharmacology.org/login.jsp and pass your own via _apiKey.

Parameters

Example call

Arguments

{
  "target_id": 1797,
  "_apiKey": "your-guidetopharmacology-api-key"
}

curl

curl -X POST https://gateway.pipeworx.io/guidetopharmacology/mcp \
  -H 'Content-Type: application/json' \
  -d '{"jsonrpc":"2.0","id":1,"method":"tools/call","params":{"name":"target_interactions","arguments":{"target_id":1797,"_apiKey":"your-guidetopharmacology-api-key"}}}'

TypeScript (@pipeworx/sdk)

import { Pipeworx } from '@pipeworx/sdk';
const pipeworx = new Pipeworx();

const result = await pipeworx.call('target_interactions', {
  "target_id": 1797,
  "_apiKey": "your-guidetopharmacology-api-key"
});

More examples

{
  "target_id": "1797",
  "limit": 50,
  "_apiKey": "your-guidetopharmacology-api-key"
}

Connect

Add this to your MCP client config — every tool in the catalog, including this one — or use one-click install buttons:

{
  "mcpServers": {
    "pipeworx": {
      "url": "https://pipeworx.io/mcp"
    }
  }
}

{
  "mcpServers": {
    "guidetopharmacology": {
      "url": "https://gateway.pipeworx.io/guidetopharmacology/mcp"
    }
  }
}

See Getting Started for client-specific install steps.