`target_interactions`

Pack: guidetopharmacology · Endpoint: https://gateway.pipeworx.io/guidetopharmacology/mcp

List the quantitative ligand interactions for a protein target in the Guide to PHARMACOLOGY (IUPHAR/BPS). Given a GtoPdb target id (from search_targets), returns the ligands acting on it with interaction type (Agonist/Antagonist/Inhibitor/etc.), action, and binding affinity (e.g. pKi/pIC50). Keyless.

Parameters

Name	Type	Required	Description
`target_id`	number,string	yes	GtoPdb target id, e.g. 1797 for EGFR.
`limit`	number	no	Max interactions to return (default 25).

Example call

Arguments

{
  "target_id": 1797
}

curl

curl -X POST https://gateway.pipeworx.io/guidetopharmacology/mcp \
  -H 'Content-Type: application/json' \
  -d '{"jsonrpc":"2.0","id":1,"method":"tools/call","params":{"name":"target_interactions","arguments":{"target_id":1797}}}'

TypeScript (@pipeworx/sdk)

import { Pipeworx } from '@pipeworx/sdk';
const pipeworx = new Pipeworx();

const result = await pipeworx.call('target_interactions', {
  "target_id": 1797
});

More examples

{
  "target_id": "1797",
  "limit": 50
}

Connect

Add this to your MCP client config, or use one-click install buttons:

{
  "mcpServers": {
    "guidetopharmacology": {
      "url": "https://gateway.pipeworx.io/guidetopharmacology/mcp"
    }
  }
}

See Getting Started for client-specific install steps.

target_interactions