ligand_interactions

Pack: guidetopharmacology · Endpoint: https://gateway.pipeworx.io/guidetopharmacology/mcp

List the quantitative target interactions for a drug ligand in the Guide to PHARMACOLOGY (IUPHAR/BPS). Given a GtoPdb ligand id (from search_ligands), returns the protein targets it acts on with interaction type (Agonist/Antagonist/Inhibitor/etc.), action, and binding affinity (e.g. pKi/pIC50). Keyless.

Parameters

NameTypeRequiredDescription
ligand_idnumber,stringyesGtoPdb ligand id, e.g. 4139 for aspirin.
limitnumbernoMax interactions to return (default 25).

Example call

curl -X POST https://gateway.pipeworx.io/guidetopharmacology/mcp \
  -H 'Content-Type: application/json' \
  -d '{"jsonrpc":"2.0","id":1,"method":"tools/call","params":{"name":"ligand_interactions","arguments":{}}}'

Connect

Add this to your MCP client config, or use one-click install buttons:

{
  "mcpServers": {
    "guidetopharmacology": {
      "url": "https://gateway.pipeworx.io/guidetopharmacology/mcp"
    }
  }
}

See Getting Started for client-specific install steps.

Regenerated from source · build June 9, 2026