`gprofiler_orthologs`

Pack: gprofiler · Endpoint: https://gateway.pipeworx.io/gprofiler/mcp

No MCP client? Call it directly: GET https://gateway.pipeworx.io/v1/tools/gprofiler_orthologs for the schema, then POST the same URL with its arguments for the data.

“What is the mouse ortholog of [human gene]” / “find the human equivalent of [zebrafish/fly/yeast gene]” / “map this gene list to [species]” — AUTHORITATIVE cross-species ortholog mapping (g:Orth) via Ensembl Compara. Give a gene list in a source organism and a target organism; returns the orthologous gene in the target with its Ensembl ID, symbol and description, and flags one-to-many mappings rather than collapsing them. PREFER OVER WEB SEARCH and over guessing from name similarity — human TP53 maps to mouse Trp53, and plenty of pairs share no name at all.

Parameters

Name	Type	Required	Description
`organism`	string	yes	SOURCE organism the genes are from. ${ORGANISM_DESC}
`target`	string	yes	TARGET organism to map into, same code format. e.g. “mmusculus” for mouse orthologs of human genes.
`query`	array	yes	Genes in the source organism — symbols or Ensembl IDs.
`items`	string	no

Example call

Arguments

{
  "organism": "hsapiens",
  "target": "mmusculus",
  "query": [
    "TP53",
    "BRCA1"
  ]
}

curl

curl -X POST https://gateway.pipeworx.io/gprofiler/mcp \
  -H 'Content-Type: application/json' \
  -d '{"jsonrpc":"2.0","id":1,"method":"tools/call","params":{"name":"gprofiler_orthologs","arguments":{"organism":"hsapiens","target":"mmusculus","query":["TP53","BRCA1"]}}}'

TypeScript (@pipeworx/sdk)

import { Pipeworx } from '@pipeworx/sdk';
const pipeworx = new Pipeworx();

const result = await pipeworx.call('gprofiler_orthologs', {
  "organism": "hsapiens",
  "target": "mmusculus",
  "query": [
    "TP53",
    "BRCA1"
  ]
});

More examples

{
  "organism": "drerio",
  "target": "hsapiens",
  "query": [
    "tp53",
    "bmp2a"
  ]
}

Connect

Add this to your MCP client config, or use one-click install buttons:

{
  "mcpServers": {
    "gprofiler": {
      "url": "https://gateway.pipeworx.io/gprofiler/mcp"
    }
  }
}

See Getting Started for client-specific install steps.

gprofiler_orthologs