`transcript`

Pack: gnomad · Endpoint: https://gateway.pipeworx.io/gnomad/mcp

Fetch gnomAD variant data for an Ensembl transcript (ENST…), returning transcript coordinates, gene symbol, chromosome position, and per-variant allele frequencies from exome and genome datasets.

Parameters

Name	Type	Required	Description
`transcript_id`	string	yes	Ensembl transcript id (ENST…)
`dataset`	string	no

Example call

Arguments

{
  "transcript_id": "ENST00000357144"
}

curl

curl -X POST https://gateway.pipeworx.io/gnomad/mcp \
  -H 'Content-Type: application/json' \
  -d '{"jsonrpc":"2.0","id":1,"method":"tools/call","params":{"name":"transcript","arguments":{"transcript_id":"ENST00000357144"}}}'

TypeScript (@pipeworx/sdk)

import { Pipeworx } from '@pipeworx/sdk';
const pipeworx = new Pipeworx();

const result = await pipeworx.call('transcript', {
  "transcript_id": "ENST00000357144"
});

More examples

{
  "transcript_id": "ENST00000380152",
  "dataset": "gnomad_r4"
}

Response shape

Field	Type	Description
`transcript`	object

Full JSON Schema

{
  "type": "object",
  "properties": {
    "transcript": {
      "type": "object",
      "properties": {
        "transcript_id": {
          "type": "string",
          "description": "Ensembl transcript ID"
        },
        "gene_symbol": {
          "type": "string",
          "description": "Gene symbol"
        },
        "chrom": {
          "type": "string",
          "description": "Chromosome"
        },
        "start": {
          "type": "number",
          "description": "Transcript start position"
        },
        "stop": {
          "type": "number",
          "description": "Transcript stop position"
        },
        "variants": {
          "type": "array",
          "items": {
            "type": "object",
            "properties": {
              "variant_id": {
                "type": "string",
                "description": "Variant identifier"
              },
              "consequence": {
                "type": "string",
                "description": "VEP consequence"
              },
              "exome": {
                "type": "object",
                "properties": {
                  "af": {
                    "type": "number",
                    "description": "Allele frequency"
                  }
                }
              },
              "genome": {
                "type": "object",
                "properties": {
                  "af": {
                    "type": "number",
                    "description": "Allele frequency"
                  }
                }
              }
            }
          }
        }
      }
    }
  }
}

Connect

Add this to your MCP client config, or use one-click install buttons:

{
  "mcpServers": {
    "gnomad": {
      "url": "https://gateway.pipeworx.io/gnomad/mcp"
    }
  }
}

See Getting Started for client-specific install steps.

transcript