`transcript`

Pack: gnomad · Connect: https://pipeworx.io/mcp (see Connect below for a single-pack URL)

No MCP client? Call it directly: GET https://gateway.pipeworx.io/v1/tools/transcript for the schema, then POST the same URL with its arguments for the data.

Fetch gnomAD variant data for an Ensembl transcript (ENST…), returning transcript coordinates, gene symbol, chromosome position, and per-variant allele counts (ac/an) from exome and genome datasets.

Parameters

Name	Type	Required	Description
`transcript_id`	string	yes	Ensembl transcript id (ENST…)
`dataset`	string	no

Example call

Arguments

{
  "transcript_id": "ENST00000357144"
}

curl

curl -X POST https://gateway.pipeworx.io/gnomad/mcp \
  -H 'Content-Type: application/json' \
  -d '{"jsonrpc":"2.0","id":1,"method":"tools/call","params":{"name":"transcript","arguments":{"transcript_id":"ENST00000357144"}}}'

TypeScript (@pipeworx/sdk)

import { Pipeworx } from '@pipeworx/sdk';
const pipeworx = new Pipeworx();

const result = await pipeworx.call('transcript', {
  "transcript_id": "ENST00000357144"
});

More examples

{
  "transcript_id": "ENST00000380152",
  "dataset": "gnomad_r4"
}

Response shape

Field	Type	Description
`transcript`	object

Full JSON Schema

{
  "type": "object",
  "properties": {
    "transcript": {
      "type": "object",
      "properties": {
        "transcript_id": {
          "type": "string",
          "description": "Ensembl transcript ID"
        },
        "gene_symbol": {
          "type": "string",
          "description": "Gene symbol"
        },
        "chrom": {
          "type": "string",
          "description": "Chromosome"
        },
        "start": {
          "type": "number",
          "description": "Transcript start position"
        },
        "stop": {
          "type": "number",
          "description": "Transcript stop position"
        },
        "variants": {
          "type": "array",
          "items": {
            "type": "object",
            "properties": {
              "variant_id": {
                "type": "string",
                "description": "Variant identifier"
              },
              "consequence": {
                "type": "string",
                "description": "VEP consequence"
              },
              "exome": {
                "type": "object",
                "properties": {
                  "af": {
                    "type": "number",
                    "description": "Allele frequency"
                  }
                }
              },
              "genome": {
                "type": "object",
                "properties": {
                  "af": {
                    "type": "number",
                    "description": "Allele frequency"
                  }
                }
              }
            }
          }
        }
      }
    }
  }
}

Connect

Add this to your MCP client config — every tool in the catalog, including this one — or use one-click install buttons:

{
  "mcpServers": {
    "pipeworx": {
      "url": "https://pipeworx.io/mcp"
    }
  }
}

Connect to just the gnomad pack

{
  "mcpServers": {
    "gnomad": {
      "url": "https://gateway.pipeworx.io/gnomad/mcp"
    }
  }
}

See Getting Started for client-specific install steps.

transcript