`ema_orphan_designations`

Pack: ema-medicines · Endpoint: https://gateway.pipeworx.io/ema-medicines/mcp

European Medicines Agency orphan medicinal product designations — active substances designated by the EU as treatments for rare diseases, which carry incentives like protocol assistance and market exclusivity. Returns the active substance, medicine name (once assigned), intended therapeutic use, EU designation number, designation status (Positive, Withdrawn, Expired, Negative) and dates. Catalyst-relevant for biotech: a positive designation often precedes a clinical or regulatory catalyst by months to years. Answers “what orphan designations has the EMA granted for rare disease X”, “is drug X an EU-designated orphan medicine”, “recent EU orphan designations”.

Parameters

Name	Type	Required	Description
`query`	string	no	Free text: active substance, medicine name, or intended-use text.
`status`	string	no	Filter on designation status: Positive, Withdrawn, Expired, or Negative.
`since`	string	no	Earliest date of designation/refusal. YYYY-MM-DD, YYYY-MM or YYYY.
`limit`	number	no	Max records, default 50, max 200.

Example call

Arguments

{
  "status": "Positive",
  "since": "2026-01"
}

curl

curl -X POST https://gateway.pipeworx.io/ema-medicines/mcp \
  -H 'Content-Type: application/json' \
  -d '{"jsonrpc":"2.0","id":1,"method":"tools/call","params":{"name":"ema_orphan_designations","arguments":{"status":"Positive","since":"2026-01"}}}'

TypeScript (@pipeworx/sdk)

import { Pipeworx } from '@pipeworx/sdk';
const pipeworx = new Pipeworx();

const result = await pipeworx.call('ema_orphan_designations', {
  "status": "Positive",
  "since": "2026-01"
});

More examples

{
  "query": "severe combined immunodeficiency",
  "limit": 5
}

Connect

Add this to your MCP client config, or use one-click install buttons:

{
  "mcpServers": {
    "ema-medicines": {
      "url": "https://gateway.pipeworx.io/ema-medicines/mcp"
    }
  }
}

See Getting Started for client-specific install steps.

ema_orphan_designations