`civic_variant_evidence`

Pack: civic · Endpoint: https://gateway.pipeworx.io/civic/mcp

No MCP client? Call it directly: GET https://gateway.pipeworx.io/v1/tools/civic_variant_evidence for the schema, then POST the same URL with its arguments for the data.

Individual CIViC evidence items for a molecular profile — the graded, source-linked statements that a variant predicts response or resistance to a therapy, carries prognostic or diagnostic weight, or is oncogenic. Each item carries evidence type, level (A-E), direction, significance, 1-5 star rating, disease, therapies and the PubMed/ASCO source. AUTHORITATIVE for the clinical evidence behind a variant claim, rather than a summary of it. Pass a molecular profile name such as “BRAF V600E”, or a numeric CIViC variant id.

Parameters

Name	Type	Required	Description
`molecular_profile`	string	no	Molecular profile name, e.g. “BRAF V600E” or “EGFR L858R”
`variant_id`	number	no	Numeric CIViC variant id (alternative to molecular_profile)
`evidence_type`	string	no	Filter: PREDICTIVE \| DIAGNOSTIC \| PROGNOSTIC \| PREDISPOSING \| ONCOGENIC \| FUNCTIONAL
`disease`	string	no	Filter by disease name substring (e.g. “Melanoma”)
`therapy`	string	no	Filter by therapy name substring (e.g. “Vemurafenib”)
`limit`	number	no	Max evidence items to return, 1-100 (default 25)

Example call

Arguments

{
  "molecular_profile": "BRAF V600E",
  "evidence_type": "PREDICTIVE",
  "limit": 3
}

curl

curl -X POST https://gateway.pipeworx.io/civic/mcp \
  -H 'Content-Type: application/json' \
  -d '{"jsonrpc":"2.0","id":1,"method":"tools/call","params":{"name":"civic_variant_evidence","arguments":{"molecular_profile":"BRAF V600E","evidence_type":"PREDICTIVE","limit":3}}}'

TypeScript (@pipeworx/sdk)

import { Pipeworx } from '@pipeworx/sdk';
const pipeworx = new Pipeworx();

const result = await pipeworx.call('civic_variant_evidence', {
  "molecular_profile": "BRAF V600E",
  "evidence_type": "PREDICTIVE",
  "limit": 3
});

Connect

Add this to your MCP client config, or use one-click install buttons:

{
  "mcpServers": {
    "civic": {
      "url": "https://gateway.pipeworx.io/civic/mcp"
    }
  }
}

See Getting Started for client-specific install steps.

civic_variant_evidence