civic_gene_variants

Pack: civic · Endpoint: https://gateway.pipeworx.io/civic/mcp

No MCP client? Call it directly: GET https://gateway.pipeworx.io/v1/tools/civic_gene_variants for the schema, then POST the same URL with its arguments for the data.

Curated variants of a cancer gene in CIViC — the specific alterations (missense, fusion, amplification, exon-level) that have published clinical interpretations, each with its evidence count, associated diseases and therapies. AUTHORITATIVE for “which variants of this gene are clinically actionable”. Pass the gene symbol.

Parameters

NameTypeRequiredDescription
genestringyesGene symbol (e.g. “BRAF”)
variant_namestringnoOptional substring filter on the variant name (e.g. “V600”)
limitnumbernoMax variants to return, 1-100 (default 25)

Example call

Arguments

{
  "gene": "BRAF",
  "variant_name": "V600",
  "limit": 5
}

curl

curl -X POST https://gateway.pipeworx.io/civic/mcp \
  -H 'Content-Type: application/json' \
  -d '{"jsonrpc":"2.0","id":1,"method":"tools/call","params":{"name":"civic_gene_variants","arguments":{"gene":"BRAF","variant_name":"V600","limit":5}}}'

TypeScript (@pipeworx/sdk)

import { Pipeworx } from '@pipeworx/sdk';
const pipeworx = new Pipeworx();

const result = await pipeworx.call('civic_gene_variants', {
  "gene": "BRAF",
  "variant_name": "V600",
  "limit": 5
});

Connect

Add this to your MCP client config, or use one-click install buttons:

{
  "mcpServers": {
    "civic": {
      "url": "https://gateway.pipeworx.io/civic/mcp"
    }
  }
}

See Getting Started for client-specific install steps.

Regenerated from source · build September 18, 2026