`civic_assertions`

Pack: civic · Endpoint: https://gateway.pipeworx.io/civic/mcp

No MCP client? Call it directly: GET https://gateway.pipeworx.io/v1/tools/civic_assertions for the schema, then POST the same URL with its arguments for the data.

CIViC assertions — the curated, AMP/ASCO/CAP-tiered and ACMG-classified clinical summaries that roll up multiple evidence items into a single actionable statement, including FDA companion-test and regulatory-approval flags. AUTHORITATIVE for “is this variant clinically actionable in this disease, and at what tier”. Filter by molecular profile, disease or therapy.

Parameters

Name	Type	Required	Description
`molecular_profile`	string	no	Molecular profile name, e.g. “BRAF V600E”
`disease`	string	no	Disease name substring (e.g. “Melanoma”)
`therapy`	string	no	Therapy name substring (e.g. “Vemurafenib”)
`limit`	number	no	Max assertions to return, 1-100 (default 25)

Example call

Arguments

{
  "molecular_profile": "BRAF V600E",
  "limit": 3
}

curl

curl -X POST https://gateway.pipeworx.io/civic/mcp \
  -H 'Content-Type: application/json' \
  -d '{"jsonrpc":"2.0","id":1,"method":"tools/call","params":{"name":"civic_assertions","arguments":{"molecular_profile":"BRAF V600E","limit":3}}}'

TypeScript (@pipeworx/sdk)

import { Pipeworx } from '@pipeworx/sdk';
const pipeworx = new Pipeworx();

const result = await pipeworx.call('civic_assertions', {
  "molecular_profile": "BRAF V600E",
  "limit": 3
});

Connect

Add this to your MCP client config, or use one-click install buttons:

{
  "mcpServers": {
    "civic": {
      "url": "https://gateway.pipeworx.io/civic/mcp"
    }
  }
}

See Getting Started for client-specific install steps.

civic_assertions