@pipeworx/civic

Connect: https://gateway.pipeworx.io/civic/mcp · Install: one-click buttons

No MCP client? Skip the connection: POST https://gateway.pipeworx.io/v1/tools/search_packs {"query":"..."} to find a tool below, GET /v1/tools/<name> for its schema, POST the same URL with arguments for the data — see For AI agents.

Tools: 4

Expert-curated clinical interpretation of cancer variants from CIViC — which somatic alterations are clinically actionable, in which disease, with which therapy, and the graded published evidence behind each claim.

Tools

• civic_search_genes(query, limit?) — cancer genes and fusions by name, with variant / evidence / assertion counts and the CIViC feature id.
• civic_gene_variants(gene, variant_name?, limit?) — the curated variants of a gene, with associated diseases and therapies.
• civic_variant_evidence(molecular_profile | variant_id, evidence_type?, disease?, therapy?, limit?) — individual evidence items with type, level A-E, direction, significance, 1-5 star rating and the PubMed/ASCO source.
• civic_assertions(molecular_profile? | disease? | therapy?, limit?) — the AMP/ASCO/CAP-tiered rollups, with FDA companion-test and regulatory-approval flags, ACMG codes and NCCN guideline.

Auth

Keyless. Public GraphQL endpoint; CIViC’s content is CC0.

Data sources

• https://civicdb.org/api/graphql — POST, {query, variables}.

Things that will otherwise cost you an afternoon:

• An explicitly null variable is a FILTER, not an absent filter — and it returns HTTP 200. Measured 2026-09-17: evidenceItems(molecularProfileName: "BRAF V600E") reports 249 matches; adding variantId: null reports 0, diseaseName: null reports 245, therapyName: null reports 313. Unset filters must be omitted from the variables map entirely. omitNulls() in src/index.ts exists for exactly this and removing it produces a silent zero.
• browseVariants.totalCount and browseFeatures.totalCount ignore their own filter arguments. browseVariants(featureName: "BRAF") and an unfiltered browseVariants both report 5029, the whole catalogue. evidenceItems and assertions DO filter their totalCount. This pack only reports the count for the two that mean it.
• description on the BrowseFeature type 500s the entire query. It is in the schema and it is not callable. The gene summary lives on the Gene type, which is why civic_search_genes makes a second call.
• genes takes entrezSymbols/entrezIds, not name. Free-text gene search is browseFeatures(featureName:) (substring, unranked — this pack re-ranks exact matches first) or featureTypeahead(queryTerm:).
• Evidence and assertion status can be SUBMITTED as well as ACCEPTED; a submitted item has not been through CIViC review yet.

Tools

• civic_search_genes — Find cancer genes and fusions in CIViC by name or symbol, with how much curated clinical evidence each carries (variant count, evidence-item count, assertion count). AUTHORITATIVE starting point for ”
• civic_gene_variants — Curated variants of a cancer gene in CIViC — the specific alterations (missense, fusion, amplification, exon-level) that have published clinical interpretations, each with its evidence count, associat
• civic_variant_evidence — Individual CIViC evidence items for a molecular profile — the graded, source-linked statements that a variant predicts response or resistance to a therapy, carries prognostic or diagnostic weight, or
• civic_assertions — CIViC assertions — the curated, AMP/ASCO/CAP-tiered and ACMG-classified clinical summaries that roll up multiple evidence items into a single actionable statement, including FDA companion-test and reg